Lidocaine 1
Dose Response study of Lidocaine 1%
Purpose:
To analyze the sensory and motor block produced by three different volumes of intrathecally lidocaine 1% and thereby determine the appropriate volume to administer for surgery of the lower limbs and perineum.
Methods Forty-eight patients scheduled for perinea or lower limb surgery were randomly assigned to receive 4, 6 or 8 ml lidocaine 1% intrathecally. The wide-spread, duration and regression of analgesia and motor block and side effects were evaluated (by a blinded observer whenever possible).
Results:
The maximum cephalic spread in the 6 ml (T8 ± 3) and 8 ml (T4 ± 1.7) groups were higher than the 4 ml group (T12 ± 2.2,P < 0.01). In the 4 ml group, six patients (33%) did not achieve analgesia to T12 and four (22%) did not have complete motor blockade. Individuals given 8 ml had longer duration of block (duration at T12: 104 ± 23vs 60 ± 24, 67 ± 14 min,P < 0.01; 8 mlvs 4, 6 ml) and slower recovery times (sensory recovery: 188 ± 27vs 142 ± 27, 157 ± 28 min,P < 0.01; 8 mlvs 4, 6 ml). Two patients (18%) from the 8 ml group and one (5%) from the 6 ml group had transient hypotension.
Conclusion:
Four milliliters intrathecally lidocaine 1% is adequate for perinea surgery but for lower limb procedures, 6 ml is more appropriate as it consistently provides sensory analgesia above L1 dermatome and complete motor block. 8 ml can effect to an unnecessarily high block with higher incidence of hypotension.
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Help on tattoo. Let me take you guys from my observing of any typical numbing cream, Actually I was making a research on which numbing cream shall be using on my new tattoo, I planned it on my upper right arm, It is my first time to do it, so I have to be exactly mind set, this are some of my researched. I had found out that numbing creams are differentiated according to the product itself, what it is contain? how long? how it works? how much it cost? more important on how the quality the product is.
What It Contains:
Lidocaine, Prilocaine, and Benzocaine, these are local anesthetics which is commonly used to reduce or relieve pain and discomforts. These are important ingredients that a numbing cream does have, but a cream should one or two of them mix, because it can harm the individual if overdoses. Drnumb contains 5% lidocaine which makes it solid and non-oily and water-based, while some contains 5% lidocaine and Prilocaine mixed(2.5% each) which made the product oil-in-water, meaning to say some product are oily that can cause errors on tattooing or in some surgical procedures, it can slip the needle or it can interfere the ink of the tattoo.
How Long It Takes:
Numbing creams are useful agent in some treatment especially tattooing. The cream must not delay or make any trouble in the activity. At first, you need to apply a thin amount of the cream in the skin surface area. You must wait for about 30 minutes while covering it with saran wrap, this application is common in every numbing cream (30 min’s wait). Then get tattooed, In this ways numbing creams differentiated, how long does it takes. An average tattoo can last long for about 2-3 hours, Drnumb cream can last up to 2 hours and 30 minutes, while some can last long for about 30 minutes, this is can cause delay and not appropriate for tattooing. A 30 grams cream should cover up a half a chest.
How it Works?
A numbing cream is a topical anesthetic that is used to reduce or refrain from sufferings of pain and discomfort from a tattoo, piercing and some minor surgery (without open wounds). It must be safe and does not swell or irritate the skin. A topical numbing cream works by blocking nerves from transmitting painful impulses to the brain. After applying a thick (quarter inch) layer of the cream to the area to be tattooed, cover the cream with saran wrap for at least 30 minutes to give enough time to ensure a painless steel tattoo. Once the air tight bandage has been removed, the skin will remain completely numb for at least two hours. It can be use in tattooing and body piercing,hair removal treatment, and minor surgical procedures.
Quality:
The numbing cream must be approved or allowed by the Food And Drugs Administration. It must be safe and has no side effects. And It must be medically proven and reasonable priced.
Now I would ask you? what shall I use in my new tattoo?
To know more about the most safe and purest numbing cream that does not interfere with any kind of permanent ink, tattoo ink or piercing process, log on to our website at http://www.drnumb.com. Or call our toll free number 1-877-786-2001
